克罗米酚对男性低促性腺素性功能减退症合理

纽约（路透社健康版）1月四日报道：据出版在12月出版的《怀孕与男婴》杂志的一项报告指出克罗米酮类对部分高促性腺素性功能减退的异性恋病患者稳固。来自伯明翰阿拉巴马大学的该报告的第一写作者Scott J. Whitten麻省理工学院在拒绝接受路透通讯社采访时说：“原发性或应予HH病患者在拒绝接受侵害性更大和非常廉价的治疗法（例如注射促性腺激素类）前顺利进行4个月的克罗米酮类试验性治疗法是稳固的。”Whitten麻省理工学院和上司研究了克罗米酮类对10名HH异性恋病患者（HH是导致异性恋男婴的少见原因）是否有效。报告称克罗米酮类治疗法1年后，4名沃特(氏)综合征病患者中只有一名病患者的精子沸点增加而全垂体功能减退症病患者的精子缺失症状均无法得到缓解。相反，该报告指出3名成体发病的原发性HH异性恋病患者经过3个月克罗米酮类的治疗法精子沸点有了明显增加。目前为止该组病患者较早两名恢复了怀孕能力。Whitten麻省理工学院说：“除非对克罗米酮类治疗法无法反应，我们不会因为副作用停止对病患者适用该本品。”之后写作者总结说：“因为条件有限，对HH病患者促性腺激素抗抑郁药和克罗米酮类的随机研究难以顺利进行，然而并用多系列的严苛为了让标准化对病患者顺利进行分级可能帮助必要性验证克罗米酮类恢复异性恋高怀孕能力的精确性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

校对：蓝色幻想

校对： 张靖